Alpha GPC
Alpha GPC
In stock

Alpha GPC

  • Category: Nootropic Compunds
Quantity Discounted price DISCOUNT
3-5 €23.08 5%$1.22
6-9 €22.36 8%$1.94
10+ €21.87 10%$2.43
Shipment will be on monday
Change your country
Country icon

Delivery time not available contact us for more information

  • Your Biohacking Experts.
  • Mo-Fr Same day shipping for orders before 17:00.
  • Free shipping for orders above 75eu.
  • Superior Quality high purity extracts and compunds.
  • Quantity based discounts applicable.
Add all to cart
Reference List

Alpha GPC (L-Alpha glycerylphosphorylcholine)

Alpha GPC (L-Alpha glycerylphosphorylcholine) is a naturally occurring cholinergic compound in the body1. Its primary function is to supply choline to the brain, where it’s transformed into acetylcholine, a neurotransmitter pivotal for cognitive functions.

This compound is renowned for potentially enhancing cognitive processes, supporting cellular health, and maintaining a balance of essential neurochemicals in the brain1. As per the European Food Safety Authority (EFSA), Alpha GPC can:

  • Support standard neurological function;
  • Contribute to memory retention and overall brain function;
  • Aid in nerve impulse transmission.

Understanding Alpha GPC

Alpha GPC, a variant of the nutrient choline, is renowned for its role in supplying choline to the brain. Once in the brain, it’s transformed into acetylcholine, a neurotransmitter essential for cognitive processes. Not only is Alpha GPC present naturally in our bodies, but it’s also abundant in choline-rich foods such as dairy products, meats, and wheat germ. Nonetheless, its pharmacological benefits are best experienced through supplementation, offering higher doses1.

Mechanism of Action

Though extensive research has been conducted on the modes of action of Alpha GPC, specific impacts on neuronal activities remain elusive. Structurally, Alpha GPC is identified as Phosphatidylcholine, a lecithin phospholipid integrated with choline. This choline is essential for the synthesis of acetylcholine, often dubbed the “learning neurotransmitter”, instrumental in numerous cognitive domains. The nootropic attributes of Alpha GPC largely revolve around this vital function.
When ingested, Alpha GPC, being water-soluble, exhibits rapid action and demonstrates high bioavailability. Most users report experiencing its benefits within an hour post-consumption. Alpha GPC provides the brain with an approximate 40% choline content2.
Its proficiency in crossing the blood-brain barrier qualifies Alpha GPC as an efficient cholinergic, surpassing even other choline sources when it comes to enhancing choline levels within the central nervous system3.

Alpha GPC has been observed to elevate the levels of serotonin4 and dopamine5, neurotransmitters pivotal in regulating mood, energy, and motivation. Additionally, it enhances phosphatidylcholine levels, aiding in the maintenance of brain’s neurochemical balance and fostering strong cell membranes. Notably, deficiencies in phosphatidylcholine are associated with neurological ailments such as dementia and schizophrenia6.

Benefits of Alpha GPC Supplementation

Alpha GPC boasts a plethora of both physical and cognitive benefits, whether consumed standalone or in synergy with other nootropics.

Enhancements in Memory and Cognition

Thanks to its potential to increase acetylcholine synthesis, a neurotransmitter, Alpha GPC serves as a potent cognitive booster. This positions it as a promising supplement for bolstering regular neurological function and improving memory. Though much research zeroes in on age-related memory deterioration, Alpha GPC displays notable memory benefits across different age groups.
In a particular study, 32 healthy young adults exhibited memory recovery post a temporary chemically induced amnesia, upon being administered Alpha GPC7. User testimonials frequently acclaim Alpha GPC’s efficacy as a nootropic that amplifies cognitive abilities while also elevating energy and motivation levels8. Further, studies suggest Alpha GPC’s capacity to stimulate the development of new brain cells and mend damaged cell membranes, fortifying regular neurological activity. It may also possess anti-aging and neuroprotective traits11.

Human Growth Hormone and Post-Exercise Recovery

The full spectrum of Alpha GPC’s ability to augment human growth hormone secretion remains under exploration. Preliminary research suggests that a 600 mg dosage of Alpha GPC taken 90 minutes prior to bench pressing could potentially enhance the power output by 14%12. Another study infers that a single dose of Alpha GPC can amplify growth hormone production and hepatic fat oxidation, characteristics linked to augmented energy levels and reduced recovery durations, in healthy males under 25 years of age13.

Recommended Dosage

A standard dosage of Bacopa monnieri typically consists of 300 mg of a standardized extract28. Being fat-soluble, it’s advised to consume Bacopa Monnieri with a fatty meal or milk30. In traditional Ayurvedic medicine, this herb is often paired with clarified butter or ghee.
While Bacopa Monnieri might show quick anxiolytic effects31, consistent intake over several weeks is necessary to realize its full cognitive-enhancing properties4.

Introduction to Alpha GPC

Alpha GPC (L-Alpha glycerylphosphorylcholine) is a natural cholinergic compound found within the body1. Recognized for its role in delivering choline to the brain, it is metabolized into the cognition-enhancing neurotransmitter, acetylcholine. This process contributes to several cognitive functions, supports cell health, and maintains a crucial neurochemical balance in the brain1. The European Food Safety Authority (EFSA) has highlighted that Alpha GPC can:

  • Facilitate normal neurological functions;
  • Preserve memory and overall brain performance;
  • Aid in the transmission of nerve impulses.

For those seeking a high-quality source, Biohacking Core Alpha GPC ensures purity and the desired effects of Alpha GPC supplementation.

Understanding Alpha GPC

A derivative of the nutrient choline, Alpha GPC facilitates choline transportation to the brain, where it gets converted to the neurotransmitter, acetylcholine, aiding cognitive function1. While naturally present in the body, choline-rich foods like dairy products, meats, and wheat germ also contain Alpha GPC. However, its pharmacological benefits are best experienced when ingested as a supplement.

Mechanism of Action

Alpha GPC’s actions are extensively studied, though its influence on specific neuronal functions remains to be fully understood. Structurally, it’s identified as phosphatidylcholine, a lecithin phospholipid connected to choline, vital for synthesizing acetylcholine, a neurotransmitter significant in many cognitive areas. The nootropic attributes of Alpha GPC largely revolve around this relationship.

Upon oral consumption, alpha GPC exhibits water solubility, which enables it to act promptly and ensures it is highly bioavailable. It is efficiently transported across the blood-brain barrier, allowing most individuals to experience its benefits within an hour post-consumption. Notably, the molecular composition of alpha GPC comprises approximately 40% choline, a significant portion of which is directed to the brain2.
Its unique ability to cross the blood-brain barrier establishes alpha GPC as a superior cholinergic compound. In comparison to other choline sources and even choline itself, alpha GPC demonstrates a heightened efficacy in augmenting choline concentrations within the central nervous system3.
Additionally, alpha GPC has the potential to elevate the levels of serotonin4 and dopamine5. Both neurotransmitters play pivotal roles in the modulation of mood, energy, and motivation. Another crucial action of alpha GPC is its contribution to phosphatidylcholine production in the body. This compound aids in upholding the neurochemical balance within the brain and fortifying cellular structures. Furthermore, a deficiency in phosphatidylcholine has been implicated in various neurological disorders, including dementia and schizophrenia6.

Alpha GPC: A Profusion of Benefits

Alpha GPC is celebrated for its manifold physical and cognitive benefits, manifesting both in its standalone use and in conjunction with other nootropics.

Enhancement of Memory and Cognitive Faculties

Through its role in bolstering the synthesis of the neurotransmitter acetylcholine, Alpha GPC is recognized as a potent cognitive booster. This property underscores its potential as a supplement geared towards preserving regular neurological function and enhancing memory recall. While the bulk of studies have centered on addressing age-associated memory decline, emerging evidence suggests that Alpha GPC offers memory benefits across diverse age groups.

In a study, the memory-recovery potential of Alpha GPC was tested on 32 healthy young adults who had temporarily induced amnesia. This study revealed that Alpha GPC could play a role in memory recovery7. On the anecdotal front, several users have reported that Alpha GPC enhances cognitive functions and simultaneously increases their energy and motivation levels8910. Further research has indicated that Alpha GPC can promote new brain cell growth and repair damaged cell membranes, which are crucial for maintaining healthy neurological functions. Some studies even propose that it may have potential anti-aging and neuroprotective effects11.

Human Growth Hormone and Post-Exercise Recovery

While extensive research on Alpha GPC’s ability to increase human growth hormone production is still pending, preliminary studies are promising. For instance, a pilot study showed that a 600 mg dose of Alpha GPC, taken 90 minutes before bench pressing, increased the power output of participants by 14%12. Another study demonstrated that a single dose of Alpha GPC heightened growth hormone production and hepatic fat oxidation in healthy men under 25. These effects are believed to be associated with higher energy production and quicker recovery periods13.

Recommended Dosage

Existing research recommends an Alpha GPC dosage of 1200 mg daily, divided into three 400-mg doses14. Nevertheless, the EFSA clarifies that there’s no standardized dosage recommendation for Alpha GPC within the EU. In contrast, the recommended dosage in the United States stands at 550 mg daily for adult males.
A dosage range between 300–1200 mg, administered in one to three doses, is generally perceived as safe and effective for the majority. As a standard practice for supplements, it’s advised to begin with the minimum effective dose and adjust based on individual needs.

1. Linder, Leah. 2018. “Alpha-GPC – An Overview”. Klaire Labs. Accessed September 8, 2022.

2. Parker, Adam G, Allyn Byars, Martin Purpura, and Ralf Jäger. 2015. “The Effects of Alpha-Glycerylphosphorylcholine, Caffeine or Placebo on Markers of Mood, Cognitive Function, Power, Speed, and Agility.” Journal of the International Society of Sports Nutrition 12 (S1).

3. Trabucchi, M., S. Govoni, and F. Battaini. 1986. “Changes in the Interaction between CNS Cholinergic and Dopaminergic Neurons Induced by L-Alpha-Glycerylphosphorylcholine, a Cholinomimetic Drug.” Il Farmaco; Edizione Scientifica 41 (4): 325–34.

4. Miyamoto, Yuji, Susumu Nakano, Mitsunori Kaneko, Hiroshi Takano, and Hikaru Matsuda. 1992. “Clinical Evaluation of a New Synthetic Protease Inhibitor in Open Heart Surgery.” ASAIO Journal 38 (3): M395–98.

5. Trabucchi, M., S. Govoni, and F. Battaini. 1986. “Changes in the Interaction between CNS Cholinergic and Dopaminergic Neurons Induced by L-Alpha-Glycerylphosphorylcholine, a Cholinomimetic Drug.” Il Farmaco; Edizione Scientifica 41 (4): 325–34.

6. Huang, Joanne H., Hyoungjun Park, Jonathan Iaconelli, Shaunna S. Berkovitch, Bradley Watmuff, Donna McPhie, Dost Öngür, Bruce M. Cohen, Clary B. Clish, and Rakesh Karmacharya. 2016. “Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines.” Journal of Proteome Research 16 (2): 481–93.

7. Canal, N., M. Franceschi, M. Alberoni, C. Castiglioni, P. De Moliner, and A. Longoni. “Effect of L-Alpha-Glyceryl-Phosphorylcholine on Amnesia Caused by Scopolamine.” International Journal of Clinical Pharmacology, Therapy, and Toxicology 29 (3): 103–7.

8. Reddit. 2018. “R/Nootropics – We Need to Fix This Global Mistake in the Sub. Alpha-Gpc Is Also Strong Nootropic.” Accessed September 8, 2022.

9. Reddit. 2013. “R/Nootropics – Alpha GPC Success!” Accessed September 8, 2022.

10. Reddit. 2016. “R/Nootropics – Alpha GPC Caught Me by Surprise.” Accessed September 8, 2022.

11. Glenn, Melissa J., Elizabeth D. Kirby, Erin M. Gibson, Sarah J. Wong-Goodrich, Tiffany J. Mellott, Jan K. Blusztajn, and Christina L. Williams. 2008. “Age-Related Declines in Exploratory Behavior and Markers of Hippocampal Plasticity Are Attenuated by Prenatal Choline Supplementation in Rats.” Brain Research 1237 (October): 110–23.

12. Parker, Adam G, Allyn Byars, Martin Purpura, and Ralf Jäger. 2015. “The Effects of Alpha-Glycerylphosphorylcholine, Caffeine or Placebo on Markers of Mood, Cognitive Function, Power, Speed, and Agility.” Journal of the International Society of Sports Nutrition 12 (S1): P41.

13. Kawamura, Takashi, Takeshi Okubo, Koji Sato, Satoshi Fujita, Kazushige Goto, Takafumi Hamaoka, and Motoyuki Iemitsu. 2012. “Glycerophosphocholine Enhances Growth Hormone Secretion and Fat Oxidation in Young Adults.” Nutrition (Burbank, Los Angeles County, Calif.) 28 (11–12): 1122–26.

14. De Jesus Moreno Moreno, Maria. 2003. “Cognitive Improvement in Mild to Moderate Alzheimer’s Dementia after Treatment with the Acetylcholine Precursor Choline Alfoscerate: A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.” Clinical Therapeutics 25 (1): 178–93.

0 reviews

Latest Blogs

But I must explain to you how all this mistaken idea of denouncing pleasure

Research on Sabroxy®

Sabroxy® is a relatively new product on the market that's been making some headlines recently. Unlike many popular nootropics, Sabroxy®...

Read More

What Is Biohacking?

While the term “biohacking” has gained momentum in recent years, its meaning can differ depending on the context in which...

Read More
What is PrimaVie Shilajit | Research on PrimaVie Shilajit | Best Research on PrimaVie Shilajit | PrimaVie Shilajit Dosage | PrimaVie Shilajit Benefits And Effects

Research on PrimaVie® Shijalit

The market is full of countless substances touted for their positive impact on brain health, cognition, mood, energy levels, and...

Read More
Background CTA

Level Up: Unearth Our Unsurpassed Quality!