Bacopa Monnieri
Bacopa Monnieri
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Bacopa Monnieri – Capsules

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Biohacking Core’s Bacopa Monnieri 500mg – Optimal Cognitive Support and Stress Relief

Embrace a legacy of cognitive enhancement and stress relief with Biohacking Core’s Bacopa Monnieri 500mg. Derived from an undying herb native to the muddy areas of India, Asia, and South America, our specially formulated supplement features a standardized extract containing 50% bacosides. Bacopa Monnieri has been cherished for centuries in traditional Ayurvedic medicine, revered for promoting health, longevity, and a fortified mind.

Whether you are striving for peak cognitive performance amidst a challenging workday or searching for natural stress relief, Biohacking Core’s Bacopa Monnieri stands as your reliable ally. Our high-quality supplement, enriched with a potent extract of Bacopa Monnieri, plays a pivotal role in sharpening your mental agility, fostering tranquility, and providing remarkable antioxidant benefits.

Why Consider Biohacking Core’s Bacopa Monnieri 500mg?

  • Associated with Cognitive Enhancement: Bacopa Monnieri’s interactions with certain biological processes have been linked to supporting memory, focus, and mental agility1. It’s hypothesized to promote the synthesis of certain molecules related to cognitive function, potentially enriching your mental dexterity.
  • Linked with Stress Relief: Due to its adaptogenic properties, Bacopa Monnieri might contribute to managing stress levels and fostering a sense of calm2. By influencing certain pathways in the body, it could potentially enhance your stress response.
  • Potential Antioxidant Properties: Bacopa Monnieri might have potent antioxidant effects, offering potential neuroprotective benefits. It is believed to play a role in protecting the brain from free radicals, thereby potentially preventing oxidative damage to brain cells and tissues3.
  • Quality Assurance: Biohacking Core’s Bacopa Monnieri is sourced from traditional cultivation regions, thereby ensuring its natural origin and potential efficacy. Each capsule is meticulously crafted to encapsulate a standardized extract of 50% bacosides, enhancing the effectiveness of Bacopa Monnieri supplementation.

Recommended Dosage:

For adults only. We recommend a daily dosage of 2 capsules (1000mg), preferably taken with food. Please consult with a healthcare professional before starting any supplementation routine.

Experience the Bacopa Monnieri Effect:

Research suggests that Bacopa Monnieri supplementation can significantly enhance cognitive function and stress management12. However, individual results can vary, and these benefits are most effectively experienced as part of a lifestyle that includes a balanced diet and regular exercise.
Embark on a journey towards enhanced cognitive health and stress relief with Biohacking Core’s Bacopa Monnieri 500mg, your trusted ally in mental performance and stress management. Integrate Biohacking Core’s Bacopa Monnieri into your wellness routine today, and navigate life’s challenges with greater mental clarity and calm.

Disclaimer: These statements have not been evaluated by the European Food Safety Authority (EFSA). This product is not intended to diagnose, treat, cure, or prevent any disease.

Bacopa Monnieri: A Perennial Herb with Proven Health Benefits

Bacopa Monnieri, native to the wetlands of India, Asia, and South America, is a perennial herb with a long-standing history in Ayurvedic medicine. Traditionally, it has been employed to combat various ailments, enhance longevity, and fortify the mind.1

The European Food Safety Authority (EFSA) recognizes Bacopa monnieri for its antioxidant properties that potentially:

  • Shield the brain against free radicals leading to cellular damage,
  • Prevent oxidative harm to brain cells and tissues.2

Mechanism of Action

Bacopa monnieri exerts diverse effects on the body, predominantly enhancing neural communication and regulating the secretion of specific neurotransmitters2.
A significant mode of its action involves promoting dendritic growth—the nerve cells’ branching extensions—and facilitating neural impulse transmission. Studies indicate that 4–6 weeks of Bacopa monnieri extract supplementation can instigate fundamental neural modifications, enhancing memory and learning capabilities3. Additionally, Bacopa monnieri stimulates nerve cells and heightens neural connections’ responsiveness to nerve impulses4. Furthermore, it augments activity within the hippocampus by increasing the activity of kinases, which are proteins pivotal for cellular pathways5.

The hippocampus plays an essential role in cognition, and the effects of Bacopa on this structure are posited to be a primary mechanism by which the herb augments cognitive functions67. Research indicates that Bacopa monnieri modulates levels of several neurotransmitters, including serotonin, catecholamine, GABA, glutamate, and notably acetylcholine, which is intricately linked to memory processes8910. Moreover, Bacopa has been observed to inhibit cholinesterase, an enzyme that degrades acetylcholine. This inhibitory action potentially enhances the function of acetylcholine711. While Bacopa doesn’t directly regulate dopamine production, it has been found to protect dopamine receptors from oxidative stress and reduce dopamine degradation8. Due to these properties, Bacopa is garnering interest as a potential therapeutic agent for Parkinson’s disease, a neurodegenerative condition characterized by decreased dopamine levels12.

Bacopa monnieri’s potential to alleviate anxiety can be attributed in part to its propensity to enhance the brain’s serotonin and GABA levels89. GABA, as an inhibitory neurotransmitter, plays a crucial role in mitigating anxiety. It achieves this by curtailing the activity of neurons that might be hyperactivated due to stress factors14.

Exploring the Benefits of Bacopa Supplements

The Composite Indian Herbal Preparation (CIHP) contains Bacopa Monnieri alongside other constituents. Research suggests it might offer benefits for soldiers deployed in high-altitude, cold, or challenging environments15. There’s a growing body of evidence that Bacopa might bolster both physical and mental resilience against stress16. Bacosides, the chemical compounds sourced from Bacopa, are believed to foster new neural connections and rejuvenate damaged nerves. Such actions contribute to enhanced memory and recall capabilities11. Additionally, Bacopa monnieri can boost the concentration of serotonin in the brain, a neurotransmitter intimately associated with relaxation and an overall sense of well-being1718.

A bacoside-rich extract has been found to reverse cognitive decline initiated by the injection of colchicine into the intracerebroventricular space, a process that starts by introducing ibotenic acid into the Nucleus basalis, a collection of neurons predominantly found in the forebrain19. The remarkable antioxidant capabilities of Bacopa monnieri can be attributed to metal chelation and its intrinsic ability to form bonds20. In a study spanning four weeks, healthy individuals were administered Bacosides A and B21. The results showcased Bacopa’s capacity to enhance visual data processing, accelerate learning, bolster memory assimilation, and reduce anxiety over a 12-week period.

A distinct study provided 40 children, aged between 6 and 8, with a daily dosage of one gram of Bacopa, either as a syrup or in powdered form22. The syrup variant demonstrated significant improvements in memory, perception, and response performance, all while exhibiting no side effects. Moreover, a single 300-mg dosage of Bacopa monnieri was found to be non-detrimental to healthy adults23. Further research indicated that even elevated doses of Bacopa posed no adverse effects24.

Studies conducted over extended periods indicate that Bacopa can favorably influence memory. One such study had 76 adults, aged between 40 to 65, who consumed Bacopa for three months25. Results demonstrated that those in the Bacopa group exhibited enhanced memory retention and a heightened capacity to assimilate new information compared to the placebo group.

While a significant volume of research investigates Bacopa’s influence on memory and cognition among the healthy population, there is also noteworthy data regarding its effect on children diagnosed with ADHD26. Even though research on this subject is ongoing27, only a limited number of studies have undergone the rigorous peer review process for publication28. A recent review identified just six of such trials, primarily focusing on Bacopa’s effects on memory29. Moreover, a meta-analysis comprising nine studies with 518 participants suggests that this herb can enhance cognitive abilities and decrease choice response time30. Several of these investigations corroborated these effects.

However, information remains scant on Bacopa’s influence on other cognitive faculties, including alertness, combined cognitive capabilities, linguistic competence, and more.

Recommended Dosage

The advised dosage for Bacopa monnieri is typically 300 mg when considering a standardized extract31.

Bacopa Monnieri has lipophilic properties, making it best absorbed when consumed with a source of fat such as fatty foods or milk30. In traditional Ayurvedic practices, this herb is commonly consumed alongside clarified butter, known as ghee.

While Bacopa Monnieri may exhibit quick anxiolytic effects31, consistent intake over several weeks is often required to fully realize its cognitive-enhancing benefits41321.

1. Herbal Gram Bacopa monnieri American Botanical Council. 2011.

2. Stough, Con, Hemant Singh, and Andrea Zangara. 2015. “Mechanisms, Efficacy, and Safety of Bacopa Monnieri (Brahmi) for Cognitive and Brain Enhancement.” Evidence-Based Complementary and Alternative Medicine : ECAM 2015.

3. Vollala, Venkata Ramana, Subramanya Upadhya, and Satheesha Nayak. 2011. “Enhancement of Basolateral Amygdaloid Neuronal Dendritic Arborization Following Bacopa Monniera Extract Treatment in Adult Rats.” Clinics 66 (4): 663–71.

4. McPhee, Grace M., Luke A. Downey, Keith A. Wesnes, and Con Stough. 2021. “The Neurocognitive Effects of Bacopa Monnieri and Cognitive Training on Markers of Brain Microstructure in Healthy Older Adults.” Frontiers in Aging Neuroscience 13 (February).

5. Leung, How-Wing, Gabriel Foo, Gokulakrishna Banumurthy, Xiaoran Chai, Sujoy Ghosh, Tora Mitra-Ganguli, and Antonius M. J. VanDongen. 2017. “The Effect of Bacopa Monnieri on Gene Expression Levels in SH-SY5Y Human Neuroblastoma Cells.” Edited by Natarajan Aravindan. PLOS ONE 12 (8): e0182984.

6. Sweatt, J.David. 2004. “Hippocampal Function in Cognition.” Psychopharmacology 174 (1).

7. Rajan, Koilmani Emmanuvel, Jayakumar Preethi, and Hemant K. Singh. 2015. “Molecular and Functional Characterization OfBacopa Monniera: A Retrospective Review.” Evidence-Based Complementary and Alternative Medicine 2015: 1–12.
8. Aguiar, Sebastian, and Thomas Borowski. 2013. “Neuropharmacological Review of the Nootropic Herb Bacopa Monnieri.” Rejuvenation Research 16 (4): 313–26.

9. Dauvermann, Maria R, Graham Lee, and Neil Dawson. 2017. “Glutamatergic Regulation of Cognition and Functional Brain Connectivity: Insights from Pharmacological, Genetic and Translational Schizophrenia Research.” British Journal of Pharmacology 174 (19): 3136–60.

10. Carhart-Harris, RL, and DJ Nutt. 2017. “Serotonin and Brain Function: A Tale of Two Receptors.” Journal of Psychopharmacology 31 (9): 1091–1120.

11. Prabhakar, Sudesh, Venugopalan Y. Vishnu, Manish Modi, Manju Mohanty, Anchal Sharma, Bikas Medhi, B. R. Mittal, et al. 2020. “Efficacy of Bacopa Monnieri (Brahmi) and Donepezil in Alzheimer’s Disease and Mild Cognitive Impairment: A Randomized Double-Blind Parallel Phase 2b Study.” Annals of Indian Academy of Neurology 23 (6): 767–73.

12. Triarhou, L. C. 2000–13. “Dopamine and Parkinson’s Disease.” In: Madame Curie Bioscience Database [Internet]. Austin, TX: Landes Bioscience.

13. Calabrese, Carlo, William L. Gregory, Michael Leo, Dale Kraemer, Kerry Bone, and Barry Oken. 2008. “Effects of a Standardized Bacopa Monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial.” The Journal of Alternative and Complementary Medicine 14 (6): 707–13.

14. Hepsomali, Piril, John A. Groeger, Jun Nishihira, and Andrew Scholey. 2020. “Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.” Frontiers in Neuroscience 14: 923.

15. Lalith Singh, T. 2004. A Herbal Stress Buster for Soldiers. Hyderabad, India: The Hindu.

16. Rai, Deepak, Gitika Bhatia, Gautam Palit, Raghwendra Pal, Satyawan Singh, and Hemant K. Singh. 2003. “Adaptogenic Effect of Bacopa Monniera (Brahmi).” Pharmacology Biochemistry and Behavior 75 (4): 823–30.

17. Charles, Prisila Dulcy, Ganesh Ambigapathy, Pitchairaj Geraldine, Mohammad Abdulkadar Akbarsha, and Koilmani Emmanuvel Rajan. 2011. “Bacopa Monniera Leaf Extract Up-Regulates Tryptophan Hydroxylase (TPH2) and Serotonin Transporter (SERT) Expression: Implications in Memory Formation.” Journal of Ethnopharmacology 134 (1): 55–61.

18. Berger, Miles, John A Gray, and Bryan L Roth. 2009. “The Expanded Biology of Serotonin.” Annual Review of Medicine 60 (1): 355–66.

19. Bhattacharya, S.K., A. Kumar and S. Ghosal. 2000. “Effect of Bacopa monniera on Animal Models of Alzheimer’s Disease and Perturbed Central Cholinergic Markers of Cognition in Rats. Research Communications in Pharmacology and Toxicology 4 (3/4), 111–2

20. Bhattacharya, S.K., and S. Ghosal. 1998. “Anxiolytic Activity of a Standardized Extract of Bacopa Monniera: An Experimental Study.” Phytomedicine 5 (2): 77–82.

21. C., Stough, Nathan P., Lloyd J., Clarke J., Hutchison C., Downey L., and Rodgers T. 2001. “The Chronic Effects of an Extract of Bacopa Monniera (Brahmi) on Cognitive Function in Healthy Human Subjects.” Psychopharmacology 156 (4): 481–84.

22. Sharma, R., C. Chaturvedi, and P. V. Tewari. 1987. “Efficacy of Bacopa monnieri in Revitalizing Intellectual Functions in Children.” Journal of Research and Education in Indian Medicine 1: 12.

23. Nathan, P. J., J. Clarke, J. Lloyd, C. W. Hutchison, L. Downey, and C. Stough. 2001. “The Acute Effects of an Extract OfBacopa Monniera (Brahmi) on Cognitive Function in Healthy Normal Subjects.” Human Psychopharmacology: Clinical and Experimental 16 (4): 345–51.

24. Downey, Luke A., James Kean, Fiona Nemeh, Angela Lau, Alex Poll, Rebecca Gregory, Margaret Murray, et al. 2012. “An Acute, Double-Blind, Placebo-Controlled Crossover Study of 320 Mg and 640 Mg Doses of a Special Extract OfBacopa Monnieri(CDRI 08) on Sustained Cognitive Performance.” Phytotherapy Research 27 (9): 1407–13.

25. Roodenrys, S. 2002. “Chronic Effects of Brahmi (Bacopa monnieri) on Human Memory.” Neuropsychopharmacology 27 (2): 279–81.

26. Srivastava, J. S., O. P. Asthana, R. C. Gupta, K. S. Negi, N. Jauhari, Y. D. Sinfh, K. P. Kushwaha, C. K. Rastogi, and A. K. Rathi. 2002. “Double Blind Placebo Controlled Randomized Study of Standardized Bacopa monniera Extract in Children with Attention Deficit Hyperactivity Disorder.” Indian Journal of Psychiatry 44 (supplement).

27. Kean, James, Jordy Kaufman, Justine Lomas, Antionette Goh, David White, David Simpson, Andrew Scholey, et al. 2015. “A Randomized Controlled Trial Investigating the Effects of a Special Extract of Bacopa Monnieri (CDRI 08) on Hyperactivity and Inattention in Male Children and Adolescents: BACHI Study Protocol (ANZCTRN12612000827831).” Nutrients 7 (12): 9931–45.

28. Pase, Matthew P., James Kean, Jerome Sarris, Chris Neale, Andrew B. Scholey, and Con Stough. 2012. “The Cognitive-Enhancing Effects of Bacopa Monnieri: A Systematic Review of Randomized, Controlled Human Clinical Trials.” The Journal of Alternative and Complementary Medicine 18 (7): 647–52.

29. Kongkeaw, Chuenjid, Piyameth Dilokthornsakul, Phurit Thanarangsarit, Nanteetip Limpeanchob, and C. Norman Scholfield. 2014. “Meta-Analysis of Randomized Controlled Trials on Cognitive Effects of Bacopa Monnieri Extract.” Journal of Ethnopharmacology 151 (1): 528–35.

30. Thakkar, VaishaliTejas, Amol Deshmukh, Lal Hingorani, Payal Juneja, Lalji Baldaniya, Asha Patel, Tosha Pandya, and Mukesh Gohel. 2017. “Development and Optimization of Dispersible Tablet of Bacopa Monnieri with Improved Functionality for Memory Enhancement.” Journal of Pharmacy and Bioallied Sciences 9 (3): 208.

31. Bhattacharya, S.K., and S. Ghosal. 1998. “Anxiolytic Activity of a Standardized Extract of Bacopa Monniera: An Experimental Study.” Phytomedicine 5 (2): 77–82.

32. Peth-Nui, Tatimah, Jintanaporn Wattanathorn, Supaporn Muchimapura, Terdthai Tong-Un, Nawanant Piyavhatkul, Poonsri Rangseekajee, Kornkanok Ingkaninan, and Sakchai Vittaya-Areekul. 2012. “Effects of 12-Week Bacopa Monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers.” Evidence-Based Complementary and Alternative Medicine: ECAM 2012: 606424.

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